Nonneoplastic disorders
Atypical regenerative hyperplasia

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 12 January 2018, last major update November 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Atypical regenerative hyperplasia esophageal

Cite this page: Weisenberg, E. Atypical regenerative hyperplasia. website. Accessed November 15th, 2018.
Definition / general
  • Associated with chronic esophagitis, not neoplasia
  • Also called reactive hyperplasia, pseudoepitheliomatous hyperplasia
Microscopic (histologic) description
  • Architectural uniformity of immature and relatively monotonous sized small / medium keratinocytes mixed with inflammatory cells
  • Pleomorphism and atypia are common in keratinocytes and endothelial cells
  • Also mitotic figures
  • No cytoarchitectural pleomorphism, no desmoplasia
Microscopic (histologic) images

Images hosted on other servers:

Squamous cell
carcinoma vs.
atypical regenerative

Various images

Differential diagnosis