Esophagus
General
Biopsy


Topic Completed: 1 August 2012

Revised: 8 February 2019

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PubMed Search: Esophagus[TI] biopsy[TI]

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Table of Contents
Definition / general
Cite this page: Weisenberg E. Biopsy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusbiopsies.html. Accessed May 26th, 2019.
Definition / general
  • For suspected tumor, 5 - 6 biopsies recommended, including edge of ulcers, base of ulcer and other nonnecrotic areas
  • Cytology samples may pick up additional cancers missed by biopsies
  • Limit a cassette to 3 - 4 biopsy fragments so they will be properly embedded
  • Recommend embedding on edge and cutting perpendicular to mucosa, although difficult to do with small biopsies
  • Immediate fixation is particularly important for lymphoid lesions
  • Common stains are Alcian blue pH 2.5 (detects acidic mucin), mucicarmine (detects acidic mucin), PAS with and without diastase (detects acidic and neutral mucin)
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