Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 4 January 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Esophagus[TI] biopsy[TI]

Table of Contents
Definition / general
Cite this page: Weisenberg, E. Biopsy. website. Accessed September 22nd, 2018.
Definition / general
  • For suspected tumor, 5 - 6 biopsies recommended, including edge of ulcers, base of ulcer and other nonnecrotic areas
  • Cytology samples may pick up additional cancers missed by biopsies
  • Limit a cassette to 3 - 4 biopsy fragments so they will be properly embedded
  • Recommend embedding on edge and cutting perpendicular to mucosa, although difficult to do with small biopsies
  • Immediate fixation is particularly important for lymphoid lesions
  • Common stains are Alcian blue pH 2.5 (detects acidic mucin), mucicarmine (detects acidic mucin), PAS with and without diastase (detects acidic and neutral mucin)