Topic Completed: 1 August 2012

Minor changes: 8 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Esophagus[TI] biopsy[TI]

Elliot Weisenberg, M.D.
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Table of Contents
Definition / general
Cite this page: Weisenberg E. Biopsy. website. Accessed June 3rd, 2020.
Definition / general
  • For suspected tumor, 5 - 6 biopsies recommended, including edge of ulcers, base of ulcer and other nonnecrotic areas
  • Cytology samples may pick up additional cancers missed by biopsies
  • Limit a cassette to 3 - 4 biopsy fragments so they will be properly embedded
  • Recommend embedding on edge and cutting perpendicular to mucosa, although difficult to do with small biopsies
  • Immediate fixation is particularly important for lymphoid lesions
  • Common stains are Alcian blue pH 2.5 (detects acidic mucin), mucicarmine (detects acidic mucin), PAS with and without diastase (detects acidic and neutral mucin)
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