Topic Completed: 1 September 2013

Revised: 26 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Choriocarcinoma esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 234
Page views in 2020 to date: 52
Cite this page: Weisenberg E. Choriocarcinoma. website. Accessed April 1st, 2020.
Definition / general
  • Germ cell tumor composed of cytotrophoblast, syncytiotrophoblast and extravillous trophoblast (WHO definition of nongestational choriocarcinoma)
  • In esophagus, may occur in pure form or combined with other malignancies
  • Extraordinarily rare - under 20 cases reported
  • Appears to be more common in distal esophagus
Clinical features
  • Very aggressive disease
  • Death within 3 months in reported cases
  • Endoscopic biopsy
  • Human chorionic gonadotropin (hCG) may elevated
Case reports
Gross description
  • Large, exophytic tumor that may encircle esophagus
  • Marked necrosis and hemorrhage
Microscopic (histologic) description
  • Mixture of syncytiotrophoblast and cytotrophoblast with extensive hemorrhage and necrosis, muscularis propria invasion
  • May have foci of adenocarcinoma or squamous cell carcinoma
  • May be associated with Barrett esophagus
Positive stains
Differential diagnosis
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