Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 January 2018, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Choriocarcinoma esophagus

Cite this page: Weisenberg, E. Choriocarcinoma. website. Accessed March 22nd, 2018.
Definition / general
  • Germ cell tumor composed of cytotrophoblast, syncytiotrophoblast and extravillous trophoblast (WHO definition of nongestational choriocarcinoma)
  • In esophagus, may occur in pure form or combined with other malignancies
  • Extraordinarily rare - under 20 cases reported
  • Appears to be more common in distal esophagus
Clinical features
  • Very aggressive disease
  • Death within 3 months in reported cases
  • Endoscopic biopsy
  • Human chorionic gonadotropin (hCG) may elevated
Case reports
Gross description
  • Large, exophytic tumor that may encircle esophagus
  • Marked necrosis and hemorrhage
Microscopic (histologic) description
  • Mixture of syncytiotrophoblast and cytotrophoblast with extensive hemorrhage and necrosis, muscularis propria invasion
  • May have foci of adenocarcinoma or squamous cell carcinoma
  • May be associated with Barrett esophagus
Positive stains
Differential diagnosis