Benign tumors
Gland duct adenoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 17 January 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Gland duct adenoma esophagus

Cite this page: Weisenberg, E. Gland duct adenoma. website. Accessed September 22nd, 2018.
Definition / general
  • Very rare
  • Immunohistochemistry is similar to normal esophageal gland submucosal duct cells
  • Usually lower half of esophagus
Case reports
  • Excision
Gross description
  • Usually polypoid or pedunculated; rarely flat
Microscopic (histologic) description
  • No capsule but well demarcated; tubulopapillary and cystic structures with eosinophilic granular cells but no atypia; basal cell layer present; interstitial lymphocytic infiltrate
  • Resembles intraductal papilloma or breast or salivary gland sialadenoma papilliferum
Positive stains
Negative stains
Electron microscopy description
  • Numerous mitochondria
Differential diagnosis