Benign tumors
Gland duct adenoma

Topic Completed: 1 December 2012

Minor changes: 15 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Gland duct adenoma esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 531
Page views in 2020 to date: 204
Cite this page: Weisenberg E. Gland duct adenoma. website. Accessed June 3rd, 2020.
Definition / general
  • Very rare
  • Immunohistochemistry is similar to normal esophageal gland submucosal duct cells
  • Usually lower half of esophagus
Case reports
  • Excision
Gross description
  • Usually polypoid or pedunculated; rarely flat
Microscopic (histologic) description
  • No capsule but well demarcated; tubulopapillary and cystic structures with eosinophilic granular cells but no atypia; basal cell layer present; interstitial lymphocytic infiltrate
  • Resembles intraductal papilloma or breast or salivary gland sialadenoma papilliferum
Positive stains
Negative stains
Electron microscopy description
  • Numerous mitochondria
Differential diagnosis
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