Benign tumors
Giant fibrovascular polyp

Topic Completed: 1 January 2013

Revised: 5 December 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Fibrovascular polyp esophagus[TIAB]

Elliot Weisenberg, M.D.
Page views in 2018: 1,443
Page views in 2019 to date: 2,271
Cite this page: Weisenberg E. Giant fibrovascular polyp. website. Accessed December 13th, 2019.
Definition / general
  • Uncommon submucosal tumor (1 - 2% of benign esophageal tumors) that arises in upper esophagus from cricopharyngeal region; may be due to redundant folds that get pulled down by force of swallowing
  • Also called fibroma, fibrolipoma, fibromyxoma, lipoma, giant fibrovascular polyp
  • May actually be an acquired malformation or hamartoma
  • Lesion is unique to esophagus
Clinical features
  • Presents with slowly worsening dysphagia or weight loss of ~10 kg
  • Benign but may cause death from asphyxia secondary to laryngeal obstruction or be regurgitated into oral cavity
  • Age 45+ years, no definite gender preference (AJR Am J Roentgenol 1996;166:781)
Case reports
Clinical images

Images hosted on other servers:

Endoscopy images

Gross description
  • Soft, elongated, pedunculated mass up to 20 cm with narrow point of attachment; overlying mucosa may be ulcerated; cut surface is yellowish tan, edematous
Gross images

AFIP images

Giant tumor is
mobilized through

Images hosted on other servers:

Core is composed of fibrous and adipose tissue

Giant polyp causing asphyxiation

Various images

Microscopic (histologic) description
  • Squamous epithelial lining with frequent ulceration; core of mature fibromyxoid tissue with scattered thin walled blood vessels and variable adipose tissue; also stromal edema and occasional lymphocytic infiltrate; may have prominent mast cells
Microscopic (histologic) images

AFIP images

Adipocytes form lobules of different sizes

Myxoid area contains spindle cells and vessels

Images hosted on other servers:

Core contains fibroadipose tissue

Figures 2 - 6

Various images (figures 8 - 10)

Differential diagnosis
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