Nonneoplastic disorders
Glycogenic acanthosis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 15 January 2018, last major update November 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Glycogenic acanthosis esophagus

Cite this page: Weisenberg, E. Glycogenic acanthosis. website. Accessed September 22nd, 2018.
Definition / general
Gross description
  • Multiple white mucosal plaques < 1 cm; may resemble leukoplakia; polypoid lesions may occur in syndromic patients
Gross images

Images hosted on PathOut server:

Numerous white islands

Slightly elevated longitudinal plaque

Images hosted on other servers:

White nodules

Microscopic (histologic) description
  • Epithelial thickening by large squamous cells of prickle cell layer packed with glycogen; no atypia, no inflammation
Microscopic (histologic) images

Images hosted on PathOut server:

Thickened superficial squamous epithelium with enlarged squamous cells containing abundant pale to clear cytoplasm

Images contributed by Dr. Mark R. Wick:

Glycogen patch

Glycogen patch undigested PAS stain

Glycogen patch digested PAS stain

Images hosted on other servers:

Large squamous cells with abundant cytoplasm

Positive stains
  • PAS (glycogen), diastase sensitive