Benign tumors
Hyperplastic polyp

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 18 January 2018, last major update January 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Hyperplastic polyp esophagus

Cite this page: Weisenberg, E. Hyperplastic polyp. website. Accessed October 20th, 2018.
Definition / general
  • Also called inflammatory esophagogastric polyp
  • Similar descriptions in literature for inflammatory and hyperplastic polyp
  • Uncommon but most common esophageal polyp, near gastroesophageal junction
  • May represent an exaggerated mucosal response to esophageal injury, including reflux associated ulceration and repair, protracted vomiting, Crohn's disease, sclerotherapy for varices, heterotopic gastric mucosa, embedded pills, infection, anastomosis
  • Usually men
  • 48% associated with GERD; 15% with Barrett esophagus; not associated with carcinoma (Am J Surg Pathol 2011;35:1038)
Case reports
Microscopic (histologic) description
  • Hyperplastic gastric type foveolar epithelium or squamous epithelium with granulation tissue, edematous lamina propria, inflammatory infiltrate; 67% have ulceration or erosion (Am J Surg Pathol 2001;25:1180)
  • Squamous hyperplastic polyps may be inverted squamous papillomas, possibly HPV+ (Am J Surg Pathol 1993;17:803)
Microscopic (histologic) images

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