Benign tumors
Hyperplastic polyp

Topic Completed: 1 January 2013

Revised: 11 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Hyperplastic polyp esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 3,979
Page views in 2020 to date: 1,060
Cite this page: Weisenberg E. Hyperplastic polyp. website. Accessed April 3rd, 2020.
Definition / general
  • Also called inflammatory esophagogastric polyp
  • Similar descriptions in literature for inflammatory and hyperplastic polyp
  • Uncommon but most common esophageal polyp, near gastroesophageal junction
  • May represent an exaggerated mucosal response to esophageal injury, including reflux associated ulceration and repair, protracted vomiting, Crohn's disease, sclerotherapy for varices, heterotopic gastric mucosa, embedded pills, infection, anastomosis
  • Usually men
  • 48% associated with GERD; 15% with Barrett esophagus; not associated with carcinoma (Am J Surg Pathol 2011;35:1038)
Case reports
Microscopic (histologic) description
  • Hyperplastic gastric type foveolar epithelium or squamous epithelium with granulation tissue, edematous lamina propria, inflammatory infiltrate; 67% have ulceration or erosion (Am J Surg Pathol 2001;25:1180)
  • Squamous hyperplastic polyps may be inverted squamous papillomas, possibly HPV+ (Am J Surg Pathol 1993;17:803)
Microscopic (histologic) images

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