Esophagus
Nonneoplastic disorders
Idiopathic muscular hypertrophy


Topic Completed: 1 December 2012

Revised: 15 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Idiopathic muscular hypertrophy esophagus


Elliot Weisenberg, M.D.
Page views in 2018: 202
Page views in 2019 to date: 178
Cite this page: Weisenberg E. Idiopathic muscular hypertrophy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusidiopathicmuscularhypertrophy.html. Accessed July 18th, 2019.
Definition / general
  • Diffuse thickening of lower esophageal and upper gastric musculature, luminal diameter usually preserved
  • Believed to be due to spasm, increased intraluminal pressure
Epidemiology
  • Adults, no gender preference, rarely familial (autosomal dominant)
Clinical features
  • Often asymptomatic; incidental finding at autopsy, sometimes detected during imaging or esophageal motility studies (Chest 1978;73:28)
  • May present with dysphagia, chest pain, vomiting, weight loss; patients often diabetic
Case reports
Gross description
  • Wall is 0.6 - 0.9 cm thick (normal is 0.25 cm)
Microscopic (histologic) description
  • Marked uniform thickening of muscularis propria, usually inner circular layer, with variable lymphocytes; no nodules
Differential diagnosis
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