Esophagus
Nonneoplastic disorders
Idiopathic muscular hypertrophy

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 16 January 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Idiopathic muscular hypertrophy esophagus

Cite this page: Weisenberg, E. Idiopathic muscular hypertrophy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusidiopathicmuscularhypertrophy.html. Accessed September 22nd, 2018.
Definition / general
  • Diffuse thickening of lower esophageal and upper gastric musculature, luminal diameter usually preserved
  • Believed to be due to spasm, increased intraluminal pressure
Epidemiology
  • Adults, no gender preference, rarely familial (autosomal dominant)
Clinical features
  • Often asymptomatic; incidental finding at autopsy, sometimes detected during imaging or esophageal motility studies (Chest 1978;73:28)
  • May present with dysphagia, chest pain, vomiting, weight loss; patients often diabetic
Case reports
Gross description
  • Wall is 0.6 - 0.9 cm thick (normal is 0.25 cm)
Microscopic (histologic) description
  • Marked uniform thickening of muscularis propria, usually inner circular layer, with variable lymphocytes; no nodules
Differential diagnosis