Esophagus
Premalignant lesions
Indefinite for dysplasia


Topic Completed: 1 May 2013

Revised: 11 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Indefinite for dysplasia esophagus[TIAB]

Elliot Weisenberg, M.D.
Page views in 2018: 918
Page views in 2019 to date: 981
Cite this page: Weisenberg E. Indefinite for dysplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusindefinite.html. Accessed October 22nd, 2019.
Definition / general
  • These patients are at risk for adenocarcinoma - rebiopsy after antireflux treatment
Diagnosis
  • Limit diagnosis to cases in which changes are too marked for negative but insufficient for dysplasia
  • Diagnosis may be due to suboptimal tissue processing, loss of surface epithelium, cautery artifact (Histopathology 2000;37:99)
Microscopic (histologic) description
  • Dysplastic-like epithelial atypia in background of active neutrophilic inflammation and mucosal erosion
  • Architecture may be moderately distorted; nuclear abnormalities less marked than dysplasia; may have more numerous dystrophic goblet cells, more extensive nuclear stratification, diminished or absent mucus production, increased cytoplasmic basophilia or increased mitoses
Microscopic (histologic) images

AFIP images
   

Crowding of lower portions of
glands with maturation towards
surface but some stratification
and nuclear enlargement

    

Enlarged, hyperchromatic, spindled and
stratified nuclei; also dystrophic
goblet cells with nuclei displaced
towards luminal surface of cell

    

Enlarged nuclei are pseudostratified
and crowded in lower crypt but
nuclear changes are less
pronounced towards surface



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Indefinite for dysplasia

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