Premalignant lesions
Indefinite for dysplasia

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 19 January 2018, last major update May 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Indefinite for dysplasia esophagus[TIAB]

Cite this page: Weisenberg, E. Indefinite for dysplasia. website. Accessed November 17th, 2018.
Definition / general
  • These patients are at risk for adenocarcinoma - rebiopsy after antireflux treatment
  • Limit diagnosis to cases in which changes are too marked for negative but insufficient for dysplasia
  • Diagnosis may be due to suboptimal tissue processing, loss of surface epithelium, cautery artifact (Histopathology 2000;37:99)
Microscopic (histologic) description
  • Dysplastic-like epithelial atypia in background of active neutrophilic inflammation and mucosal erosion
  • Architecture may be moderately distorted; nuclear abnormalities less marked than dysplasia; may have more numerous dystrophic goblet cells, more extensive nuclear stratification, diminished or absent mucus production, increased cytoplasmic basophilia or increased mitoses
Microscopic (histologic) images

Images hosted on PathOut server:

Crowding of lower portions of glands with maturation towards surface but some stratification and nuclear enlargement

Enlarged, hyperchromatic, spindled and stratified nuclei; also dystrophic goblet cells with nuclei displaced towards luminal surface of cell

Enlarged nuclei are pseudostratified and crowded in lower crypt but nuclear changes are less pronounced towards surface

Images hosted on other servers:

Various images

Indefinite for dysplasia