Benign tumors

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 18 January 2018, last major update January 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Leiomyomatosis esophagus

Page views in 2018: 170
Page views in 2019 to date: 25
Cite this page: Weisenberg, E. Leiomyomatosis. website. Accessed January 23rd, 2019.
Definition / general
Case reports
Gross description
  • Confluent muscle masses involving most of esophageal length, usually inner circular muscularis propria
Gross images

Images hosted on PathOut server:

Massively thickened distal esophagus

Microscopic (histologic) description
  • Diffusely nodular, hypertrophic and disorganized muscularis propria
  • Nodules are continuous with each other and identical to leiomyomas with whorled or fascicular growth of hypertrophied smooth muscle cells
  • Thickened small submucosal vessels and hypertrophied myenteric nerve plexus; variable collagen
Microscopic (histologic) images

Images hosted on PathOut server:

Multiple seedling leiomyomas

Enlarged smooth muscle bundles

Differential diagnosis