Benign tumors

Topic Completed: 1 January 2013

Revised: 15 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Leiomyomatosis esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 222
Page views in 2020 to date: 102
Cite this page: Weisenberg E. Leiomyomatosis. website. Accessed April 1st, 2020.
Definition / general
Case reports
Gross description
  • Confluent muscle masses involving most of esophageal length, usually inner circular muscularis propria
Gross images

AFIP images

Massively thickened distal esophagus

Microscopic (histologic) description
  • Diffusely nodular, hypertrophic and disorganized muscularis propria
  • Nodules are continuous with each other and identical to leiomyomas with whorled or fascicular growth of hypertrophied smooth muscle cells
  • Thickened small submucosal vessels and hypertrophied myenteric nerve plexus; variable collagen
Microscopic (histologic) images

AFIP images

Multiple seedling leiomyomas

Enlarged smooth muscle bundles

Differential diagnosis
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