Lymphoepithelioma-like carcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 January 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Lymphoepithelioma-like carcinoma esophagus

Cite this page: Weisenberg, E. Lymphoepithelioma-like. website. Accessed July 23rd, 2018.
Definition / general
  • Rare primary esophageal malignancy with same histologic appearance as undifferentiated nonkeratinizing carcinoma of nasopharynx
  • May have better prognosis than other carcinomas
  • Very rare; most reports from Japan
Clinical features
  • Generally similar to squamous cell carcinoma; in one report presented like leiomyoma with nonprogressive course
  • Endoscopic biopsy
Prognostic factors
  • In some case reports and anecdotally from reports in stomach, likely better prognosis than conventional adenocarcinoma or squamous cell carcinoma
Case reports
  • Naspharyngeal carcinoma is treated with radiation therapy
Clinical images

Images hosted on other servers:

Elevated tumor

Microscopic (histologic) description
  • Variable numbers of primitive epithelial cells with lymphocytic infiltrate with variable plasma cells
Microscopic (histologic) images

Images hosted on other servers:

Located under squamous epithelium

Various immunostains

EBV associated molecules

Lymphocytic markers

Positive stains
Differential diagnosis