Lymphoepithelioma-like carcinoma

Topic Completed: 1 October 2013

Revised: 12 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Lymphoepithelioma-like carcinoma esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 234
Page views in 2020 to date: 62
Cite this page: Weisenberg E. Lymphoepithelioma-like. website. Accessed April 3rd, 2020.
Definition / general
  • Rare primary esophageal malignancy with same histologic appearance as undifferentiated nonkeratinizing carcinoma of nasopharynx
  • May have better prognosis than other carcinomas
  • Very rare; most reports from Japan
Clinical features
  • Generally similar to squamous cell carcinoma; in one report presented like leiomyoma with nonprogressive course
  • Endoscopic biopsy
Prognostic factors
  • In some case reports and anecdotally from reports in stomach, likely better prognosis than conventional adenocarcinoma or squamous cell carcinoma
Case reports
  • Naspharyngeal carcinoma is treated with radiation therapy
Clinical images

Images hosted on other servers:

Elevated tumor

Microscopic (histologic) description
  • Variable numbers of primitive epithelial cells with lymphocytic infiltrate with variable plasma cells
Microscopic (histologic) images

Images hosted on other servers:

Located under squamous epithelium

Various immunostains

EBV associated molecules

Lymphocytic markers

Positive stains
Differential diagnosis
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