Esophagus
Carcinoma
Paget disease


Topic Completed: 1 December 2013

Revised: 27 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Paget disease esophagus

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Cite this page: Weisenberg E. Paget disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophaguspaget.html. Accessed June 16th, 2019.
Definition / general
  • Carcinoma characterized by the presence of malignant glandular epithelial cells within the squamous epithelium of the esophagus (paralleling WHO definition of Paget disease of nipple)
  • While Paget disease in the nipple has been reported without underlying malignancy, essentially all reported cases in the esophagus have underlying carcinoma
Epidemiology
  • May occur in 5% of esophageal resections for adenocarcinoma
  • Cases reported with underlying adenocarcinoma, mucous gland carcinoma and adenosquamous carcinoma (Am J Surg Pathol 2008;32:1068)
Clinical features
  • Occurs due to spread from underlying malignancy
  • In rare cases, may serve as a marker of underlying malignancy
Diagnosis
  • Endoscopic biopsy or resection
Prognostic factors
  • Prognosis related to underlying malignancy
Case reports
Microscopic (histologic) description
  • Glandular differentiation or mucin production by intraepithelial Paget cells
Positive stains
Negative stains
Differential diagnosis
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