Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 June 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Pills sticking in esophagus cause local injury, often in mid-esophagus (J Clin Gastroenterol 1999;28:298)
- Often doxycycline and other antibiotics, aspirin and NSAIDs, slow-release potassium, ferrous salts, alendronate (Fosamax, Mod Pathol 1999;12:1152)
- Associated with diabetes and ischemic heart disease (Endoscopy 2005;37:740), advanced age; more common in women
- May rarely cause strictures
- Prevention: take pills when upright and with adequate fluids (Curr Treat Options Gastroenterol 2004;7:71, Drug Saf 2000;22:237)
- Endoscopy: erosions, kissing ulcers, multiple small ulcerations with bleeding, mainly in mid-esophagus
Well-demarcated round ulcers
- Inflammatory exudate, ulceration, inflamed granulation tissue, prominent eosinophils, necrotic squamous epithelium, polarizable crystalline foreign material, multinucleated giant cells
- Fungi or viral inclusions present in 20% of cases due to alendronate
End of Esophagus > Esophagitis > Pill induced
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