Pleomorphic giant cell carcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 23 January 2018, last major update January 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Pleomorphic giant cell carcinoma esophagus

Cite this page: Weisenberg, E. Pleomorphic giant cell carcinoma. website. Accessed November 17th, 2018.
Definition / general
  • Very rare (< 5 single cases)
  • Carcinoma comprised of markedly pleomorphic epithelioid and giant cells
  • Presence of neurosecretory granules and neuroendocrine markers in one case and combined with small cell carcinoma in a second suggest possible neuroendocrine origin
Clinical features
  • Highly aggressive
  • Tissue biopsy
Case reports
Microscopic (histologic) description
  • Solid sheets of poorly cohesive epithelioid cells with numerous giant cells showing phagocytosis
Microscopic (histologic) images

Images hosted on other servers:

12 cm fungating ulcerated tumor / multinucleated tumor giant cells

Positive stains
Electron microscopy description
  • Neurosecretory granules
Electron microscopy images

Images hosted on other servers:

Neurosecretory granules

Differential diagnosis