Pleomorphic giant cell carcinoma

Topic Completed: 1 January 2014

Minor changes: 16 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Pleomorphic giant cell carcinoma esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 219
Page views in 2020 to date: 94
Cite this page: Weisenberg E. Pleomorphic giant cell carcinoma. website. Accessed June 3rd, 2020.
Definition / general
  • Very rare (< 5 single cases)
  • Carcinoma comprised of markedly pleomorphic epithelioid and giant cells
  • Presence of neurosecretory granules and neuroendocrine markers in one case and combined with small cell carcinoma in a second suggest possible neuroendocrine origin
Clinical features
  • Highly aggressive
  • Tissue biopsy
Case reports
Microscopic (histologic) description
  • Solid sheets of poorly cohesive epithelioid cells with numerous giant cells showing phagocytosis
Microscopic (histologic) images

Images hosted on other servers:

12 cm fungating ulcerated tumor / multinucleated tumor giant cells

Positive stains
Electron microscopy description
  • Neurosecretory granules
Electron microscopy images

Images hosted on other servers:

Neurosecretory granules

Differential diagnosis
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