Esophagus
Carcinoma
Pleomorphic giant cell carcinoma


Topic Completed: 1 January 2014

Revised: 16 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic giant cell carcinoma esophagus


Elliot Weisenberg, M.D.
Page views in 2018: 209
Page views in 2019 to date: 196
Cite this page: Weisenberg E. Pleomorphic giant cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophaguspleomorphic.html. Accessed November 19th, 2019.
Definition / general
  • Very rare (< 5 single cases)
  • Carcinoma comprised of markedly pleomorphic epithelioid and giant cells
Etiology
  • Presence of neurosecretory granules and neuroendocrine markers in one case and combined with small cell carcinoma in a second suggest possible neuroendocrine origin
Clinical features
  • Highly aggressive
Diagnosis
  • Tissue biopsy
Case reports
Microscopic (histologic) description
  • Solid sheets of poorly cohesive epithelioid cells with numerous giant cells showing phagocytosis
Microscopic (histologic) images

Images hosted on other servers:

12 cm fungating ulcerated tumor / multinucleated tumor giant cells

Positive stains
Electron microscopy description
  • Neurosecretory granules
Electron microscopy images

Images hosted on other servers:

Neurosecretory granules

Differential diagnosis
Back to top