Premalignant lesions
Polypoid dysplasia

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 19 January 2018, last major update May 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Polypoid dysplasia esophagus

Cite this page: Weisenberg, E. Polypoid dysplasia. website. Accessed November 21st, 2018.
Definition / general
  • Found within Barrett esophagus, resembles colonic adenoma (well defined sessile or pedunculated polyp, usually 0.5 - 1.5 cm) but often associated with invasive adenocarcinoma (Hum Pathol 1999;30:745) so recommended to not use "adenoma" terminology; may resemble dysplasia in ulcerative colitis
  • 2% of all dysplasia seen in Barrett esophagus
  • Clinical, pathological and molecular features are similar to flat Barrett dysplasia, less often has a pyloric gland phenotype (Virchows Arch 2005;446:537)
Case reports
Gross description
  • Well defined sessile or pedunculated polypoid lesion, 4 to 15 mm
Microscopic (histologic) description
  • Adenocarcinoma may be present within polyp