Premalignant lesions
Polypoid dysplasia

Topic Completed: 1 May 2013

Revised: 25 February 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Polypoid dysplasia esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 656
Page views in 2020 to date: 171
Cite this page: Weisenberg E. Polypoid dysplasia. website. Accessed April 1st, 2020.
Definition / general
  • Found within Barrett esophagus, resembles colonic adenoma (well defined sessile or pedunculated polyp, usually 0.5 - 1.5 cm) but often associated with invasive adenocarcinoma (Hum Pathol 1999;30:745) so recommended to not use "adenoma" terminology; may resemble dysplasia in ulcerative colitis
  • 2% of all dysplasia seen in Barrett esophagus
  • Clinical, pathological and molecular features are similar to flat Barrett dysplasia, less often has a pyloric gland phenotype (Virchows Arch 2005;446:537)
Case reports
Gross description
  • Well defined sessile or pedunculated polypoid lesion, 4 to 15 mm
Microscopic (histologic) description
  • Adenocarcinoma may be present within polyp
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