Secondary achalasia (pseudoachalasia)
Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 14 June 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- 2-4% of patients with achalasia-like syndrome
- Difficult to diagnosis
- Resembles achalasia, but has different pathology
- Usually associated with a neoplasm, often adenocarcinoma at/near the esophagogastric junction invading into myenteric plexus (Am J Surg Pathol 2002;26:784, Scand J Gastroenterol 2005;40:378)
- May be due to Chagas disease
- Rarely due to a paraneoplastic process (Dis Esophagus 2007;20:168), documented by anti-neuronal antibodies
- Reversal of achalasia-like symptoms after treatment of underlying disorder in most cases; reports of successful treatment of secondary achalasis from Chagas disease with Botulin toxin (Dis Esoph 2003;16:33)
Squamous cell carcinoma
End of Esophagus > Non-neoplastic disorders > Secondary achalasia (pseudoachalasia)
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