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General
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Diagnosis
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Gross images
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Fungating/exophytic:

Upper esophagus

Middle esophagus

Lower esophagus


Large mass with fungating pattern



Ulcerative:

Small tumor of mid esophagus

Prominent edges surround ulcer

Huge ulcerating carcinoma

Distal esophagus


Exophytic ulcerated mass



Infiltrative:

Elevated plaque

Carcinomatous stricture



Other:

Tumor of mid esophagus

Causing tracheo-esophageal fistulas

Granular surface


Pseudosarcomatous squamous cell carcinoma


With lymph node metastasis - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Contributed by Dr. Elliot Weisenberg




Micro description
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Micro images
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Well differentiated:



Moderately differentiated:

Pink cytoplasmic keratin

Trabecular growth



Poorly differentiated:

Moderately to poorly differentiated

Without clear-cut squamous differentiation



Other:

Undermining surface epithelium

Infiltrating nests of tumor

Intercellular bridges

Infiltration of lamina propria

Carcinoma without desmoplasia

Desmoplastic stroma in adventitia


Expansile growth pattern

Infiltrative growth pattern

Focal glandular component

Small cell type

Perineural invasion


Lymphatic invasion

Intramural venous invasion

Residual tumor after radiation therapy

Radiated tumor cells


Intramural invasion likely due to lymphatic spread

CD44 staining (fig 1A/1B)

With possible incipient invasion at base

In situ carcinoma and submucosal invasion

In situ carcinoma

Contributed by: Dr. Elliot Weisenberg

Intramural - contributed by Dr. Mark R. Wick

Keratinizing type - contributed by Dr. Mark R. Wick

Contributed by Dr. Mark R. Wick

Ulcer-associated florid regenerative squamous proliferation


Pseudosarcomatous squamous cell carcinoma

Stromal differentiation




Virtual slides
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Squamous cell carcinoma #1

#2 with liver metastases

Cytology description
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Positive stains
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Electron microscopy images
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Desmosomes and tonofilaments (site unknown)

Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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End of Esophagus > Carcinoma > Squamous cell carcinoma



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