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General
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Terminology
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Epidemiology
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Sites
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Pathophysiology
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Clinical features
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Diagnosis
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Radiology
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Case reports
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Treatment
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Clinical images
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Tumor of the lower esophagus

Prophylactic irradiation

Esophagogram before and after treatment

Endoscopic picture before and after treatment

Gross images
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Bulky, ulcerated, infiltrative lesion

Small cell carcinoma (upper),
squamous cell carcinoma (lower)

Micro description
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Micro images
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Diffusely infiltrating sheets of small cells

In situ component

Squamous cell differentiation

Ribbons and rosettes

Ribbons of cells with angular hyperchromatic nuclei

Spindle cells with scant cytoplasm,
salt and pepper nuclei
with indistinct nucleoli


Nested or organoid growth pattern most common

Biopsy specimen

With squamous cell carcinoma

Paraesophageal lymph nodes



Fig 1/2: H&E, fig 3: cytokeratin, fig 4: synaptophysin, fig 5: NSE

Immunostains - CD56, Syn, CK, and EMA

Cytology description
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Positive stains
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Electron microscopy images
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Dense core neurosecretory granules

Molecular / cytogenetics description
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Differential diagnosis
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End of Esophagus > Carcinoma > Small cell neuroendocrine carcinoma



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