Esophagus
Nonneoplastic disorders
Ulcer


Topic Completed: 1 December 2012

Revised: 10 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Ulcer[TI] esophageal[TI] full text[sb]


Elliot Weisenberg, M.D.
Page views in 2018: 1,697
Page views in 2019 to date: 2,589
Cite this page: Weisenberg E. Ulcer. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusulcer.html. Accessed October 22nd, 2019.
Definition / general
  • Usually caused by chronic gastroesophageal reflux
  • Consider infectious causes if exudate present
  • Also consider drugs, radiation, dermatologic disease, rheumatologic disorders (Yonsei Med J 2002;43:457)
Case reports
Clinical images

Images hosted on other servers:

Mid esophageal ulcer due to azithromycin

Microscopic (histologic) description
  • Granulation tissue with scattered large, atypical mesenchymal cells resembling carcinoma but not forming solid clusters
  • Adjacent epithelium has reactive changes and prominent hyperplasia (pseudoepitheliomatous hyperplasia) that appear as uniformly thick, parallel prongs of primitive squamous cells that penetrate the granulation tissue of the ulcer bed
  • Cells have minimal cytoplasm, large pleomorphic and hyperchromatic nuclei and prominent nucleoli
  • Mitotic figures common
  • May appear invasive with tangential sectioning
Microscopic (histologic) images

AFIP images

Surface of healing ulcer

Large abnormal spindle cells

Long prongs of undifferentiated cells



Images hosted on other servers:

Granulation tissue overlying submucosal glands

Negative stains
  • Atypical cells in ulcer bed are keratin negative
Back to top