Esophagus
Carcinoma
Verrucous squamous cell carcinoma


Topic Completed: 1 March 2014

Revised: 4 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Verrucous squamous cell carcinoma esophagus


Elliot Weisenberg, M.D.
Page views in 2018: 827
Page views in 2019 to date: 609
Cite this page: Weisenberg E. Verrucous squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/esophagusverrucousscc.html. Accessed July 22nd, 2019.
Definition / general
  • Highly differentiated variant of squamous cell carcinoma that is locally invasive with a pushing, as opposed to an infiltrative border, that is identical to lesions of the same name in the upper aerodigestive tract
  • Metastases are uncommon
Epidemiology
  • Extremely rare
  • Male predominance
  • Ages 36 - 76 years
Pathophysiology / etiology
Clinical features
Diagnosis
  • Tissue biopsy, knowledge of clinical and endoscopic findings may be essential to prevent misdiagnosis
Radiology images

Images hosted on other servers:

Mass penetrating the muscularis propria

Case reports
Treatment
Clinical images

Images hosted on other servers:

Large polypoid mass

Gross description
  • Large, exophytic, polypoid, generally circumferential mass
Gross images

AFIP images

Large plaque of carcinoma

Microscopic (histologic) description
  • Similar to oral cavity counterpart
  • Well differentiated with papillary fronds covered by squamous epithelium
  • Bland cytologic features with mild atypia
  • Variable parakeratosis and hyperkeratosis
  • Pushing type of invasion with blunt epithelial projections
Microscopic (histologic) images

AFIP images

Squamous spikes covered by keratin



Images hosted on other servers:

Giant cell foreign body reaction

Differential diagnosis
Back to top