Verrucous squamous cell carcinoma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 24 January 2018, last major update March 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Verrucous squamous cell carcinoma esophagus

Cite this page: Weisenberg, E. Verrucous squamous cell carcinoma. website. Accessed November 17th, 2018.
Definition / general
  • Highly differentiated variant of squamous cell carcinoma that is locally invasive with a pushing, as opposed to an infiltrative border, that is identical to lesions of the same name in the upper aerodigestive tract
  • Metastases are uncommon
  • Extremely rare
  • Male predominance
  • Ages 36 - 76 years
Pathophysiology / etiology
Clinical features
  • Tissue biopsy, knowledge of clinical and endoscopic findings may be essential to prevent misdiagnosis
Radiology images

Images hosted on other servers:

Mass penetrating the muscularis propria

Thickened esophagus

Image taken at level of CT scan

Level of carina

Barium radiograph

Case reports
Clinical images

Images hosted on other servers:

Large polypoid mass

Gross description
  • Large, exophytic, polypoid, generally circumferential mass
Gross images

Images hosted on PathOut server:

Large plaque of carcinoma

Microscopic (histologic) description
  • Similar to oral cavity counterpart
  • Well differentiated with papillary fronds covered by squamous epithelium
  • Bland cytologic features with mild atypia
  • Variable parakeratosis and hyperkeratosis
  • Pushing type of invasion with blunt epithelial projections
Microscopic (histologic) images

Images hosted on PathOut server:

Squamous spikes covered by keratin

Images hosted on other servers:

Hyperplastic squamous epithelium

Squamous epithelium with parakeratosis and mild cytologic atypia

Esophageal mucosa

Open biopsy of mediastinum

Giant cell foreign body reaction

Differential diagnosis