Eyelid inflammatory disorders
Chalazion of eyelid

Topic Completed: 1 February 2014

Minor changes: 24 May 2020

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Chalazion [title] of eyelid

Nat Pernick, M.D.
Page views in 2019: 11,207
Page views in 2020 to date: 3,707
Cite this page: Pernick N. Eyelid: chalazion of eyelid. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyechalazion.html. Accessed May 28th, 2020.
Definition / general
  • Very common
  • Deep seated lipogranuloma that develops near meibomian glands or glands of Zeis
  • Probably due to obstruction and nonspecific inflammation (blepharitis), leading to discharge of sebaceous material into surrounding tissue and resulting intense granulomatous inflammatory reaction
  • May erupt through conjunctival surface of eyelid
  • Initial specimens are often not submitted for pathologic examination but recurrences suggest sebaceous carcinoma and should be examined
  • Curettage
Microscopic (histologic) description
  • Multiple foci of granulomatous inflammation with microabscesses and multinucleated giant cells
  • Center of granulomas may contain small fat globules
Microscopic (histologic) images

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Differential diagnosis
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