Eye
General
Congenital rubella syndrome

Author: Deepali Jain, M.D. (see Authors page)

Revised: 27 April 2018 last major update March 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Congenital rubella syndrome [title] eye

Cite this page: Jain, D. General: congenital rubella syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecongenitalrubellasyndrome.html. Accessed July 21st, 2018.
Definition / general
  • Associated with cataracts (90%), iris abnormalities, retinopathy, congenital glaucoma, microphthalmos (Indian J Ophthalmol 2002;50:307)
  • Cataracts are due to retention of cell nucleus in lens cells (nuclear cataract)
  • Rubella virus can survive within these cells for years; surgery on these infants may cause uveitis or endophthalmitis due to release of virus; cataract surgery has less than optimal results (J AAPOS 2003;7:91)
  • Iris abnormalities include poorly developed dilator muscle and necrotic appearing epithelium; granulomatous inflammation is common; iris looks leathery since it doesn't dilate normally
  • Rubella retinopathy consists of alternating atrophy and hypertrophy of retinal pigment epithelium (salt and pepper appearance); may have subretinal neovascularization
  • Incidence of 0.6 per 1000 live births in Oman (Arch Ophthalmol 2004;122:541)
  • Disease persists in industrialized countries in those infected prior to 1969 vaccine (Optometry 2002;73:418)
Clinical images

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Various CRS images