Congenital rubella syndrome

Topic Completed: 1 March 2013

Revised: 25 September 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Congenital rubella syndrome [title] eye

Deepali Jain, M.D.
Page views in 2019: 162
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Cite this page: Jain D. General: congenital rubella syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecongenitalrubellasyndrome.html. Accessed April 9th, 2020.
Definition / general
  • Associated with cataracts (90%), iris abnormalities, retinopathy, congenital glaucoma, microphthalmos (Indian J Ophthalmol 2002;50:307)
  • Cataracts are due to retention of cell nucleus in lens cells (nuclear cataract)
  • Rubella virus can survive within these cells for years; surgery on these infants may cause uveitis or endophthalmitis due to release of virus; cataract surgery has less than optimal results (J AAPOS 2003;7:91)
  • Iris abnormalities include poorly developed dilator muscle and necrotic appearing epithelium; granulomatous inflammation is common; iris looks leathery since it doesn't dilate normally
  • Rubella retinopathy consists of alternating atrophy and hypertrophy of retinal pigment epithelium (salt and pepper appearance); may have subretinal neovascularization
  • Incidence of 0.6 per 1000 live births in Oman (Arch Ophthalmol 2004;122:541)
  • Disease persists in industrialized countries in those infected prior to 1969 vaccine (Optometry 2002;73:418)
Clinical images

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Various CRS images

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