Eye
Conjunctiva
Carcinoma in situ


Topic Completed: 1 September 2013

Revised: 27 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Carcinoma in situ conjunctiva [title]

Nat Pernick, M.D.
Page views in 2018: 834
Page views in 2019 to date: 862
Cite this page: Pernick N. Conjunctiva: carcinoma in situ. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjCIS.html. Accessed December 8th, 2019.
Definition / general
Treatment
  • Cryotherapy or topical chemotherapy is preferable to surgery to preserve goblet cells and lacrimal gland ductules and prevent a painful dry eye that may compromise vision (Klin Monbl Augenheilkd 2001;21:429)
Gross description
  • Leukoplakia or fleshy mass with increased vascularity
Gross images

AFIP images
Missing Image

Circumlimbal lesion

Microscopic (histologic) description
  • Full thickness changes including loss of epithelial polarity, cytologic atypia
  • Pleomorphism and mitotic figures
  • No extension of atypical cells beyond basal lamina of conjunctival epithelium
  • Resembles dysplastic changes in cervix, Bowen disease or Paget disease of skin
Microscopic (histologic) images

AFIP images
Missing Image

Full thickness atypia

Missing Image

Marked nuclear pleomorphism

Missing Image

Loss of polarity and high N/C ratio

Missing Image

Limbal lesion with extension into cornea

Missing Image

Irregular acanthosis simulating invasion

Negative stains
  • PAS (due to lack of maturation)
Differential diagnosis
  • Dysplasia: atypia is less than full thickness
Back to top