Eye
Conjunctiva
Mucoepidermoid carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 April 2018, last major update September 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Mucoepidermoid carcinoma conjunctiva

Cite this page: Pernick, N. Conjunctiva: mucoepidermoid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjMEC.html. Accessed August 20th, 2018.
Definition / general
  • Rare
  • Mean age 67 years
  • Locally aggressive with orbital and intraocular invasion, may metastasize to regional lymph nodes, lung, bone
  • More aggressive than squamous cell carcinoma
  • Often misdiagnosed because mucin is missed
Case reports
Treatment
Clinical images

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Large, fleshy, vascular,
multilobulated mass

Microscopic (histologic) description
  • Resembles squamous cell carcinoma but with mucus secreting cells, intermediate cells, epidermoid squamous cells and intraepithelial mucin
  • Usually no squamous pearls
Microscopic (histologic) images

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Limbal tumor with deep corneal invasion

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Neoplastic squamous
cells with intra- and
extracellular vacuoles

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Islands of neoplastic
squamous cells with
scattered vacuoles

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Infiltrating tumor



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Fig 1: focal mucin production (PAS)

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Fig 4: intraocular neoplastic cyst



Clear cell variant
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Fig 2: clear cells mimicking pagetoid spread

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Fig 3: lobules of clear cells with islands of squamous cells

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Fig 4: clear cells showing
marked nuclear
pleomorphism
and mitotic figures

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Fig 5: intracytoplasmic PAS+ granules

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Fig 6: Mucicarmine+

Differential diagnosis