Adenoid squamous carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 26 April 2018, last major update September 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Adenoid squamous carcinoma conjunctiva

Cite this page: Pernick, N. Conjunctiva: adenoid squamous carcinoma of conjunctiva. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjadenoidsquamous.html. Accessed September 21st, 2018.
Definition / general
  • Also called:
    • Pseudoglandular squamous cell carcinoma
    • Acantholytic squamous cell carcinoma
  • More aggressive than squamous cell carcinoma due to recurrence or infiltration of deep orbital tissue
  • Limbus or bulbar conjunctiva
  • Surgical excision with negative margins and frequent follow up
Clinical images

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Irritated superior bulbar
conjunctival mass

Microscopic (histologic) description
  • Islands of malignant squamous cells with acantholysis or pseudoglandular spaces
Microscopic (histologic) images

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Island of tumor cells

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Pseudoglandular pattern
due to acantholysis of
neoplastic squamous cells

Negative stains
Electron microscopy images

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Epithelial cells with microvillous processes

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Intracytoplasmic short collagen
fibrils and desmosomal connections

Additional references