Eye
Conjunctiva
Giant papillary conjunctivitis


Topic Completed: 1 October 2013

Revised: 27 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Giant papillary conjunctivitis [title]

Deepali Jain, M.D.
Page views in 2018: 367
Page views in 2019 to date: 297
Cite this page: Jain D. Conjunctiva: giant papillary conjunctivitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjgiantpapillary.html. Accessed August 22nd, 2019.
Definition / general
  • Noninfectious inflammatory disorder due to mechanical and immunologic processes (type I and type IV hypersensitivity)
Terminology
  • Also known as "contact lens induced papillary conjunctivitis"
Epidemiology
  • Young adults with history of atopy
  • 1 - 5% of soft contact lens wearers
  • Average onset after 10 - 20 months of contact lens use
Etiology
Clinical features
  • Itching, burning, foreign body sensation, redness
  • Mucus accumulating in inner canthus noticed in morning
  • Blurred vision, contact lens coating
  • Usually bilateral (10% unilateral)
Diagnosis
  • Upper tarsal conjunctiva has inflammation and papules (usually > 0.3 mm)
Treatment
Clinical images

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Giant papillary conjunctivitis

Microscopic (histologic) description
  • Thickened and irregular epithelium
  • Epithelial cells show polymorphism with greater number of conjunctival goblet cells
  • Upper tarsal conjunctival biopsies show mast cells, eosinophils and basophils in epithelium and substantia propria
Cytology description
Differential diagnosis
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