Eye
Conjunctiva
Kaposi sarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 27 April 2018, last major update September 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Kaposi sarcoma conjunctiva

Cite this page: Pernick, N. Conjunctiva: Kaposi sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjkaposi.html. Accessed November 14th, 2018.
Definition / general
  • See also Soft Tissue chapter
  • Historically present in up to 20% of AIDS patients
  • First manifestation of disease in 4 - 14%
  • Dugel classification (Ophthalmology 1992;99:1127)
  • Type I: patchy, flat, < 3 mm thick, thin dilated vascular channels lined by endothelial cells, no spindle cells, no mitotic activity
  • Type II: flat tumors < 3 mm thick, empty vascular channels linked by plump, fusiform endothelial cells with hyperchromatic nuclei, few spindle cells, no mitotic figures
  • Type III: nodular, 3 mm or more, packed spindle cells with hyperchromatic nuclei and mitotic figures, slit-like spaces with RBCs
Case reports
Treatment
  • Local excision with 1 - 2 mm margins plus cryotherapy
  • Type III tumors often recur
Clinical images

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Elevated nodule arising from fornix



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Multinodular conjunctival mass

Microscopic (histologic) description
  • Swollen endothelial type cells with slit-like vessels
  • Advanced lesions have spindle cells and mitotic figures
Microscopic (histologic) images

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Subepithelial proliferation of spindle cells and vessels

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Biphasic subepithelial tumor

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Swollen endothelial cells

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Enlarged endothelial cell contains a cluster of hyaline globules



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Spindle cells with extravasated RBCs

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Scattered endothelial lined spaces