Eye
Conjunctiva
Lymphoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 April 2018, last major update September 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma conjunctiva [title]

Cite this page: Pernick, N. Conjunctiva: lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjlymphoma.html. Accessed September 20th, 2018.
Definition / general
  • Usually indolent MALT lymphomas - difficult to predict malignant potential
  • Often remains an isolated lesion
  • May be preceded by apparently reactive lymphoid hyperplasia
  • Mantle cell lymphomas have more aggressive behavior with median survival of 3 - 5 years
Diagnosis
  • H&E for high grade lesions
  • For low grade lesions, need fresh tissue for flow cytometry or gene rearrangement studies
  • Immunohistochemistry (light chain restriction)
Case reports
Treatment
Gross description
  • Salmon colored mass or masses
Microscopic (histologic) description
  • MALT: well differentiated, monoclonal small B lymphocytes, occasionally exhibits overt monocytoid cytology, prominent plasmacytic features or lymphoepithelial lesions (Am J Surg Pathol 2007;31:792)
Molecular / cytogenetics description
  • MALT may have t(14;18)(q32;q21) involving IgH and MALT1 genes
  • B cell clonality in 55% of MALT and 60% of diffuse large B cell lymphomas (Mod Pathol 2001;14:641)
Additional references