Spindle cell carcinoma

Topic Completed: 1 September 2013

Revised: 27 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Spindle cell carcinoma [title] conjunctiva [title]

Nat Pernick, M.D.
Page views in 2018: 211
Page views in 2019 to date: 130
Cite this page: Pernick N. Conjunctiva: spindle cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeconjspindlecell.html. Accessed September 23rd, 2019.
Definition / general
  • Rare but more aggressive than squamous cell carcinoma
  • Elderly patients
  • Complete excision
  • May recur or invade sclera or intraocular contents
Gross description
  • Elevated or flat, smooth surface, red
  • Arises from limbus or bulbar conjunctiva
Microscopic (histologic) description
  • Spindle cells are continuous with surface epithelium
  • Have oval vesicular nuclei with large eosinophilic or basophilic nucleoli
  • Often transition to squamous cells with individual cell keratinization
  • Also acanthosis, mitotic activity, desmoplasia, variable dysplasia
Microscopic (histologic) images

AFIP images
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Sarcomatous pattern

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Large subepithelial tumor with
deep scleral and corneal invasion

Positive stains
Electron microscopy description
  • Desmosomes, tonofibrils
Differential diagnosis
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