Eye
Cornea
Acanthamoeba keratitis


Topic Completed: 1 October 2013

Revised: 27 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Acanthamoeba keratitis [title] pathology

Nat Pernick, M.D.
Page views in 2018: 435
Page views in 2019 to date: 432
Cite this page: Pernick N. Cornea: acanthamoeba keratitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneaacanthamoeba.html. Accessed October 15th, 2019.
Definition / general
  • Rare but serious complication of contact lenses due to contamination of contact lens cleaning systems
  • Organisms are ubiquitous protozoa in soil and fresh water
  • Infections wax and wane, may infiltrate cornea along corneal nerve and cause pain
Microscopic (histologic) description
  • Stromal neutrophils, necrotic tissue
  • Amoebic cysts and trophozoites identifiable with H&E, highlighted with GMS, PAS
Differential diagnosis
  • Fungal or herpetic keratitis
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