Eye
Cornea
Acanthamoeba keratitis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 May 2018, last major update October 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Acanthamoeba keratitis [title] pathology

Cite this page: Pernick, N. Cornea : acanthamoeba keratitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneaacanthamoeba.html. Accessed November 17th, 2018.
Definition / general
  • Rare but serious complication of contact lenses due to contamination of contact lens cleaning systems
  • Organisms are ubiquitous protozoa in soil and fresh water
  • Infections wax and wane, may infiltrate cornea along corneal nerve and cause pain
Microscopic (histologic) description
  • Stromal neutrophils, necrotic tissue
  • Amoebic cysts and trophozoites identifiable with H&E, highlighted with GMS, PAS
Differential diagnosis
  • Fungal or herpetic keratitis