Graft failure

Topic Completed: 1 October 2013

Minor changes: 29 June 2020

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Graft failure of cornea [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Graft failure. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneagraftfailure.html. Accessed July 10th, 2020.
Definition / general
  • Most corneal transplants are successful and provide long term improvement in visual acuity
  • Matching of donor and recipient tissue is not necessary for corneal transplants since no lymphatics or blood vessels in corneal stroma
  • Graft failure may be due to surgical damage of endothelium, immunologic rejection (uncommon) or recurrence of dystrophy
Microscopic (histologic) description
  • Fibrosis, vascularization, inflammatory cell infiltrate
  • Full thickness scars from prior surgery are present at edge of specimen
  • 50% have fibrous retrocorneal membrane
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