Infectious keratitis (keratoconjunctivitis)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 May 2018, last major update October 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Infectious keratitis keratoconjunctivitis pathology

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Cite this page: Pernick, N. Cornea: infectious keratitis (keratoconjunctivitis). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneainfectiouskeratitis.html. Accessed February 17th, 2019.
Definition / general
  • Contact lens wearers are susceptible to Pseudomonas and Acanthamoeba
  • Keratitis caused by microfilaria of Onchocerca volvulus is the leading cause of blindness worldwide, outside US
Granulomatous keratitis
  • Due to HSV1, juvenile xanthogranuloma, leprosy, sarcoidosis
Microscopic (histologic) description
  • Similar histologic findings for all organisms
  • Destruction of corneal epithelium, Bowman layer and stroma
  • Necrosis and prominent neutrophils
  • Discontinuities of Descemet membrane with corneal perforation
  • Crystal-like stromal opacities with Streptococcus viridans
  • May need special stains to detect organisms