Ulceration of cornea

Topic Completed: 1 October 2013

Minor changes: 27 March 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Ulceration [title] of cornea [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Cornea: ulceration of cornea. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneaulceration.html. Accessed May 29th, 2020.
Definition / general
  • Due to any process that causes uneven distribution of the tear film across cornea
  • Bacterial ulcers often destroy epithelium and Bowman layer with variable stromal destruction; due to Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Klebsiella, Pseudomonas
  • Complications include corneal perforation and scarring
  • Fungal ulcers occur 8 - 15 days after trauma, usually involving vegetative matter; due to Candida, Aspergillus, Cephalosporium, Fusarium
  • Satellite lesions are also present
  • Rarely due to ocular cicatricial pemphigoid (Eur J Ophthalmol 2007;17:121)
Case reports
Microscopic (histologic) description
  • Eosinophils and granulomas with fungal infection
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