Ulceration of cornea

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 May 2018, last major update October 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Ulceration [title] of cornea [title]

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Cite this page: Pernick, N. Cornea: ulceration of cornea. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyecorneaulceration.html. Accessed January 23rd, 2019.
Definition / general
  • Due to any process that causes uneven distribution of the tear film across cornea
  • Bacterial ulcers often destroy epithelium and Bowman layer with variable stromal destruction; due to Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Klebsiella, Pseudomonas
  • Complications include corneal perforation and scarring
  • Fungal ulcers occur 8 - 15 days after trauma, usually involving vegetative matter; due to Candida, Aspergillus, Cephalosporium, Fusarium
  • Satellite lesions are also present
  • Rarely due to ocular cicatricial pemphigoid (Eur J Ophthalmol 2007;17:121)
Case reports
Microscopic (histologic) description
  • Eosinophils and granulomas with fungal infection