Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Glaucoma [title] pathology [title]

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Cite this page: Pernick, N. Glaucoma: general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglaucomageneral.html. Accessed December 18th, 2018.
Definition / general
  • Diverse etiologies, causes widespread degeneration of ocular tissue
  • Defined as optic neuropathy with distinct excavation of optic nerve head and incremental loss of visual field sensitivity
  • Almost always due to increased intraocular pressure (due to impaired outflow of aqueous humor) which causes optic nerve damage and degenerative changes below
Normal circulation of aqueous humor
  • Aqueous humor is produced by pars plicata of ciliary body, discharged into posterior chamber, flows between lens and iris, through pupil, into anterior chamber, then through trabecular meshwork (in deep layers of peripheral cornea just in front of angle of anterior chamber), into Schlemm canal, leaves eye via plexus of intrascleral and episcleral veins along limbus

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Anterior chamber

Microscopic (histologic) images

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Iris and ciliary body with open anterior chamber angle