Secondary glaucoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Secondary glaucoma [title] pathology

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Table of Contents
Definition / general | Causes
Cite this page: Pernick, N. Glaucoma: secondary glaucoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglaucomasecondary.html. Accessed January 23rd, 2019.
Definition / general
  • Due to known or suspected antecedent disease, such as trauma, inflammation, tumor or malformation
  • May be open or closed angle
  • Common sites of obstruction are pupil and angle of anterior chamber
  • Formation of pupillary membranes due to organization of hemorrhage or exudates or posterior synechiae secondary to iritis
  • Peripheral anterior synechiae (adhesions between root of iris and peripheral cornea)
  • Particulate matter clogging passages (red blood cells after hemorrhage; white blood cells after uveitis; lens proteins; iris pigment epithelial granules; melanoma or other tumor cells)
  • Epithelial downgrowth from conjunctiva or cornea after trauma, fibrous downgrowth due to corneal wound
  • Rubeosis iridis
  • Blunt trauma with retrodisplacement of iris root insertion and atrophy of ciliary body
  • Surface ocular vascular malformations that increase pressure on surface of eye, such as Sturge-Weber syndrome or arterialization in episcleral veins due to fistula
  • Melanomalytic glaucoma: a type of secondary open angle glaucoma in melanoma patients with pigment laded macrophages that clog the trabecular meshwork