Topic Completed: 1 February 2014

Minor changes: 15 November 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Eye globe [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Globe: general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglobegeneral.html. Accessed May 28th, 2020.
Definition / general
  • Defined as eyeball itself plus intraocular tissues, or eye proper without its appendages
  • Dimensions: anterior-posterior 24 mm, vertical and horizontal dimensions are both 23 to 23.5 mm
  • Six extraocular muscles:
    • 4 rectus and 2 oblique muscles
    • Arise in posterior orbit from fibrous ring called annulus of Zinn, and insert into sclera
    • Muscles are surrounded by fascia
    • Inferior oblique inserts on sclera, other muscles insert on tendons
  • Equator: midway between anterior and posterior poles
  • Specimen is the result of enucleation, performed because eye is nonfunctional, painful, unsightly, infectious, contains neoplasm, post-trauma (may be removed to prevent sympathetic uveitis) or has chronic glaucoma
  • Globe usually intact but free of extraocular muscles and orbital fat
  • Globe may be eviscerated, with only fragments available for microscopic study
  • Initial pathologic processes may be obscured by subsequent pathologic processes
Pathologic processes
  • Enucleation: due to tumor (48%, usually melanoma), glaucoma (13%), phthisis bulbi (12%), recent trauma (11%)
  • Specimens also received after evisceration (10%) or exenteration (9%) to manage malignant orbital tumors (Am J Clin Pathol 2003;119:594)
  • During 1990 to 2000, decrease in percentages due to neoplasms, increase due to glaucoma and phthisis bulbi
Microscopic (histologic) images

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