Inflammation of globe

Topic Completed: 1 February 2014

Minor changes: 3 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Acute inflammation [title] globe

Nat Pernick, M.D.
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Cite this page: Pernick N. Globe: inflammation of globe. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglobeinflammation.html. Accessed May 28th, 2020.
Acute inflammation
  • Usually infectious (bacteria or fungi, usually posttraumatic, also from intravenous drug use or hematogenous spread of infection)
  • Noninfectious cause is massive necrosis of uveal melanoma or metastatic carcinoma
  • Cataract surgery may cause mild endophthalmitis due to Propionibacterium acnes
  • Initially endophthalmitis (affects intraocular contents including vitreous humor but not sclera or cornea) - massive purulent reaction in anterior and vitreous chambers
  • Later panophthalmitis (involvement of retina, choroid, sclera or orbit)
  • Panophthalmitis exposes orbit to microorganisms but endophthalmitis does not
  • Late complication is Phthisis bulbi
Chronic inflammation
Granulomatous inflammation
  • Toxoplasmosis, tuberculosis, syphilis, nematodiasis, CMV, sarcoidosis, collagen vascular diseases
  • Often cannot determine etiology
  • Diagnostic lesions often found in retina, vitreous or sclera
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