Eye
Globe
Lymphoma of globe

Author: Nat Pernick, M.D. (see Authors page)

Revised: 9 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma [title] globe review[ptyp]

Cite this page: Pernick, N. Globe: lymphoma of globe. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglobelymphoma.html. Accessed November 17th, 2018.
Definition / general
  • Rare
  • Usually associated with extraocular disease, often in CNS
  • May involve optic nerve
  • Involving ocular adnexa: mean age 64 years, slight female predominance, usually no other history of lymphoma
  • Most common subtyes are marginal zone (52%), follicular (23%) (Am J Surg Pathol 2007;31:170)
Primary intraocular lymphomas
  • Considered a component of primary CNS lymphoma
  • Are usually diffuse large B cell lymphomas with IgH heavy chain gene rearrangements
  • Some cases in HIV1 negative patients may be related to Toxoplasma gondii infection (Mod Pathol 2001;14:995)
Case reports
Clinical images

Images hosted on PathOut server:
Missing Image

Yellow-white hemorrhagic retinal infiltrates

Gross images

Images hosted on PathOut server:
Missing Image

Focally hemorrhagic white infiltrate



Images hosted on other servers:
Missing Image

1C: mass lesion of vitreous with choiroidal thickening

Microscopic (histologic) images

Images hosted on PathOut server:

Diffuse large B cell lymphoma
Missing Image

Involvement of optic nerve head

Missing Image

Detached retinal
pigment epithelium
and Bruch membrane

Missing Image Missing Image

Viable and necrotic tumor cells between detached retinal pigment epithelium and Bruch membrane




Lymphoblastic lymphoma
Missing Image

Intravascular and perivascular
retinal involvement




B cell lymphoma, unspecified
Missing Image

B and T cell immunostains



Images hosted on other servers:

Diffuse large B cell lymphoma
Missing Image

Various images

Cytology images

Images hosted on PathOut server:
Missing Image

Large atypical lymphocytes

Missing Image

Marked variation in lymphocyte size

Missing Image

B cell staining