Eye
Globe
Lymphoma of globe


Topic Completed: 1 February 2014

Revised: 1 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma [title] globe review[ptyp]

Nat Pernick, M.D.
Page views in 2018: 161
Page views in 2019 to date: 102
Cite this page: Pernick N. Globe: lymphoma of globe. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglobelymphoma.html. Accessed August 25th, 2019.
Definition / general
  • Rare
  • Usually associated with extraocular disease, often in CNS
  • May involve optic nerve
  • Involving ocular adnexa: mean age 64 years, slight female predominance, usually no other history of lymphoma
  • Most common subtyes are marginal zone (52%), follicular (23%) (Am J Surg Pathol 2007;31:170)
Primary intraocular lymphomas
  • Considered a component of primary CNS lymphoma
  • Are usually diffuse large B cell lymphomas with IgH heavy chain gene rearrangements
  • Some cases in HIV1 negative patients may be related to Toxoplasma gondii infection (Mod Pathol 2001;14:995)
Case reports
Clinical images

AFIP images
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Yellow-white hemorrhagic retinal infiltrates

Gross images

AFIP images
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Focally hemorrhagic white infiltrate



Images hosted on other servers:
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1C: mass lesion of vitreous with choiroidal thickening

Microscopic (histologic) images

AFIP images

Diffuse large B cell lymphoma
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Involvement of optic nerve head

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Detached retinal
pigment epithelium
and Bruch membrane

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Viable and necrotic tumor cells between detached retinal pigment epithelium and Bruch membrane



Lymphoblastic lymphoma
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Intravascular and perivascular
retinal involvement


B cell lymphoma, unspecified
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B and T cell immunostains



Images hosted on other servers:

Diffuse large B cell lymphoma
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Various images

Cytology images

AFIP images
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Large atypical lymphocytes

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Marked variation in lymphocyte size

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B cell staining

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