Metastases to globe

Topic Completed: 1 February 2014

Minor changes: 1 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Metastases [title] globe review[ptyp]

Nat Pernick, M.D.
Page views in 2019: 35
Page views in 2020 to date: 16
Cite this page: Pernick N. Globe: metastases to globe. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeglobemetastases.html. Accessed May 28th, 2020.
Definition / general
  • Metastatic carcinoma common but asymptomatic (breast, lung, GI tract)
  • Also metastatic melanoma or sarcoma; rarely carcinoid (Hum Pathol 1982;13:459)
  • Most common site is posterior choroid which is diffusely thickened on both sides of optic nerve
  • Metastases to eye often suggests extremely short survival and treatment is usually palliative radiation therapy
Whole mount images

AFIP images

Metastatic adenocarcinoma
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Iris and ciliary body involvement

Microscopic (histologic) images

AFIP images
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Choroidal infiltration by
poorly differentiated

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Glandular pattern of tumor cells

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