Author: Deepali Jain, M.D. (see Authors page)

Revised: 19 April 2018, last major update October 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Keratoacanthoma conjunctiva

Cite this page: Jain, D. Conjunctiva: keratoacanthoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyekeratoacanthoma.html. Accessed September 21st, 2018.
Definition / general
  • Uncommon, rapidly growing, squamous cell proliferation of sun exposed bulbar conjunctiva
  • Grows for weeks, then regresses or stays unchanged
Case reports
  • Excision; may need cryotherapy of margins due to possibility of malignant diagnosis; only rarely recurs
Clinical images

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White, dome shaped mass

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1.2 cm lesion at nasal bulbar conjunctiva

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Mobile conjunctival mass

Gross description
  • Crater like
Microscopic (histologic) description
  • Lobules of proliferating squamous epithelium, often mitotic figures
  • Deep edges are well circumscribed and regular appearing
  • Epithelial cells are glassy with vesicular nuclei and prominent eosinophilic nucleoli
  • No / rare parakeratosis
  • Often acute and chronic inflammatory cells which extend into adjacent epithelium
Microscopic (histologic) images

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Central crater containing keratotic plug

Differential diagnosis