Lacrimal duct / gland
Pleomorphic adenoma

Topic Completed: 1 February 2014

Minor changes: 23 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic adenoma [title] lacrimal gland

Nat Pernick, M.D.
Page views in 2019: 760
Page views in 2020 to date: 298
Cite this page: Pernick N. Lacrimal duct: pleomorphic adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelacrimalpleomorphicadenoma.html. Accessed May 28th, 2020.
Definition / general
  • 50 - 60% of lacrimal gland tumors
  • Resemble salivary gland tumors of same type
  • Excisional biopsy with negative margins to prevent recurrence and implantation within the orbit
Microscopic (histologic) description
  • Usually encapsulated, composed of benign epithelial and myxoid mesenchymal elements
  • Often prominent component of S100+ hyaline cells (presumed myoepithelial origin) with diffuse eosinophilic staining
  • May have squamous metaplasia, bone, cartilage or fat
Microscopic (histologic) images

AFIP images
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Well circumscribed
lacrimal gland tumor

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Islands of epithelial cells, myxoid stroma and cysts

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Double layer of epithelial cells within a myxoid stroma

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Chondroid differentiation

With carcinoma
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Large round nodule of pleomorphic
adenoma surrounded by smaller
nodules of adenocarcinoma
that have infiltrated the orbit

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Left: benign ducts within
myxoid stroma
Right: adenocarcinoma

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With adenoid cystic carcinoma

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