Lacrimal duct / gland
Transitional cell carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Transitional cell carcinoma [title] lacrimal

Page views in 2018: 165
Page views in 2019 to date: 10
Cite this page: Pernick, N. Lacrimal duct: transitional cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelacrimaltcc.html. Accessed January 23rd, 2019.
Definition / general
  • #2 lacrimal sac carcinoma after squamous cell carcinoma
  • May cause death if inadequate or delayed therapy
Poor prognostic factors
  • Marked pleomorphism
  • Numerous mitotic figures
  • Stromal invasion
Case reports
  • Extensive surgical excision and radiation therapy
  • 50% recur and recurrences may cause death
Microscopic (histologic) description
  • Exophytic and endophytic papillary lesions
  • Increased cellularity with spindled elongated cells and goblet cells
  • May have nuclear pleomorphism and mitotic figures
Microscopic (histologic) images

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Fig. 1 - papillary epithelium

Differential diagnosis