Lacrimal duct / gland
Transitional cell carcinoma

Topic Completed: 1 February 2014

Minor changes: 18 November 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Transitional cell carcinoma [title] lacrimal

Nat Pernick, M.D.
Page views in 2019: 160
Page views in 2020 to date: 88
Cite this page: Pernick N. Lacrimal duct: transitional cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelacrimaltcc.html. Accessed May 29th, 2020.
Definition / general
  • #2 lacrimal sac carcinoma after squamous cell carcinoma
  • May cause death if inadequate or delayed therapy
Poor prognostic factors
  • Marked pleomorphism
  • Numerous mitotic figures
  • Stromal invasion
Case reports
  • Extensive surgical excision and radiation therapy
  • 50% recur and recurrences may cause death
Microscopic (histologic) description
  • Exophytic and endophytic papillary lesions
  • Increased cellularity with spindled elongated cells and goblet cells
  • May have nuclear pleomorphism and mitotic figures
Microscopic (histologic) images

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Fig. 1 - papillary epithelium

Differential diagnosis
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