Lens and vitreous
Alport syndrome

Topic Completed: 1 February 2014

Revised: 2 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Alport syndrome [title] review[ptyp]

Nat Pernick, M.D.
Page views in 2019: 35
Page views in 2020 to date: 1
Cite this page: Pernick N. Lens and vitreous: Alport syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelensalport.html. Accessed February 19th, 2020.
Definition / general
  • Also called hereditary nephritis
  • Inherited disorder of type IV collagen in basement membranes
  • Hematuria, progressive nephritis with proteinuria and declining renal function, deafness (55%), ocular abnormalities (15 - 30%)
Ocular abnormalities
  • Anterior lenticonus (forward central protrusion of anterior surface of lens due to weakness in type IV collagen, relatively specific for Alport)
  • Also keratoconus, spherophakia (small, spherical lens), myopia, retinal flecks, cataracts, retinitis pigmentosa, amaurosis (blindness without an apparent ocular cause)
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