Eye
Lens and vitreous
General

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Lens and vitreous [title] review[ptyp]

Cite this page: Pernick, N. Lens and vitreous: general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelensgeneral.html. Accessed October 17th, 2018.
Definition / general
  • Most surgical specimens are cataracts or prosthetic intraocular lens
  • Normal lens is biconvex, behind pupil / iris, in front of vitreous, in posterior chamber
  • 10 mm in diameter by 4 - 5 mm in width
  • Usually Gross Examination Only (report as transparent - Yes or No), don't section
  • Anterior lens capsule is eosinophilic acellular band overlying single layer of epithelial cells
  • Lens capsule is strongly PAS+, holds lens in place
  • Lens has thinner capsule posteriorly, without epithelial cells
  • Lens in held in place by zonules that connect to pars plicata of ciliary body
  • Lens normally opacifies with age due to globules of degenerate lens fibers
  • Is a closed epithelial system with lens capsule (epithelium) that totally envelops the lens
  • Vitreous humor:
    • Avascular
    • Extends from lens to sensory retina
    • Contains gel-like material composed of water, protein, hyaluronic acid and "hyalocytes"
    • Gel consistency is due to randomly oriented collagen fibrils
    • May appear as amorphous material on H&E
Drawings

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Lens

Microscopic (histologic) description
  • Anterior but not posterior lens has single epithelial layer
Microscopic (histologic) images

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Lens