Lens and vitreous
Phacoanaphylactic endophthalmitis

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Phacoanaphylactic endophthalmitis [title]

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Cite this page: Pernick, N. Lens and vitreous: phacoanaphylactic endophthalmitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyelensphacoanaphylaxis.html. Accessed January 23rd, 2019.
Definition / general
  • Usually occurs after penetrating injuries to lens
  • Rarely due to spontaneous rupture of swollen lens with a cataract
  • Granulomatous reaction may be due to acquired hypersensitivity to lens proteins
  • May coexist with sympathetic uveitis
Microscopic (histologic) description
  • Granulomatous inflammation surrounding area of lens perforation, with zonal pattern of central neutrophils around disintegrating lens fibers and peripheral macrophages, epithelioid cells and giant cells
  • Posterior synechiae usually present
  • Usually perivasculitis of retinal vessels
  • Variable plasma cells in iris