Ocular cicatricial pemphigoid

Author: Deepali Jain, M.D. (see Authors page)

Revised: 20 April 2018, last major update April 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Ocular cicatricial pemphigoid conjunctiva [title]

Cite this page: Jain, D. Conjunctiva: ocular cicatricial pemphigoid . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeocularcicatricialpemphigoid.html. Accessed November 14th, 2018.
Definition / general
  • Also called mucus membrane pemphigoid of conjunctiva
  • Mucocutaneous autoimmune disorder
  • Bilateral; only rarely unilateral (Cornea 2010;29:1462)
  • Usually age 50+ years, more common in women
  • 50% of cases involve conjunctiva, usually 10 years or more after onset of cutaneous or other mucosal disease; may occasionally demonstrate purely ocular disease (Ophthalmology 1999;106:355)
  • Uncontrolled cases are associated with infection (Cornea 2004;23:819)
  • Rarely presents with corneal ulceration (Eur J Ophthalmol 2007;17:121)
  • Impression cytology may be useful for diagnosis (Arch Soc Esp Oftalmol 2004;79:67)
  • Divide sample in two - one for formalin, one in transport media for immunofluorescent studies
Case reports
Clinical images

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Cicatrizing conjunctivitis

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Slit lamp photograph showing bullae

Microscopic (histologic) description
  • Early - epithelial erosions and bullae
  • Late - epithelial and stromal scarring, perivascular lymphocytes and plasma cells
Microscopic (histologic) images

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Inflamed conjunctiva

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Subepidermal bullous dermatosis

Positive stains
Electron microscopy description
Differential diagnosis