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Orbit and optic nerve
Hemangiopericytoma of orbit

Nat Pernick, M.D.

Topic Completed: 1 February 2014

Minor changes: 19 February 2020

Copyright: 2004-2020, PathologyOutlines.com, Inc.

PubMed Search: Hemangiopericytoma [title] orbit

Nat Pernick, M.D.
Page views in 2019: 317
Page views in 2020 to date: 139
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis
Cite this page: Pernick N. Orbit and optic nerve: hemangiopericytoma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitHPC.html. Accessed May 28th, 2020.
Definition / general
  • Resembles solitary fibrous tumor but prominent vessels
  • 30% recur, 15% metastasize (lung, liver, bone, regional lymph nodes), usually late
  • Histology does not predict behavior (Hum Pathol 1982;13:210)
Case reports
Microscopic (histologic) description
  • Usually encapsulated
  • Random pattern of polygonal and rounded cells with ill defined cytoplasm, variable nucleoli
  • Staghorn vascular pattern and perivascular collagen, dense pericellular reticulin, occasional mitotic figures
  • Must rule out other tumors with this pattern
Microscopic (histologic) images

AFIP images
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Small polyhedral cells surround vascular spaces

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Vascular channels have a staghorn pattern

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Cells are polyhedral and spindled, with mild atypia

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Metastatic liver nodule




Images hosted on other servers:
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A-large left orbital mass
B-random pattern of polygonal and rounded cells
C-large and small vessels with staghorn pattern
D-reticulin densely surrounds each cell

Positive stains
Differential diagnosis
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