Orbit and optic nerve
Alveolar soft part sarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Alveolar soft part sarcoma orbit

Cite this page: Pernick, N. Orbit and optic nerve: alveolar soft part sarcoma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitalveolarsoftparts.html. Accessed December 17th, 2018.
Definition / general
  • Indolent, similar to tumor at other sites
  • May have late metastases
  • Mean age 23 years, range 1 - 69 years; 76% women
Microscopic (histologic) description
  • Organoid pattern outlined by thin walled capillaries, composed of nests of large polyhedral cells with abundant, finely granular, eosinophilic cytoplasm
Positive stains
  • PAS+ diastase resistant crystalline structures
Differential diagnosis
  • Alveolar rhabdomyosarcoma
  • Amelanotic melanoma
  • Granular cell tumor
  • Metastatic renal cell carcinoma
  • Paraganglioma
  • Vascular tumor
Additional references