Orbit and optic nerve
Alveolar soft part sarcoma

Topic Completed: 1 February 2014

Minor changes: 3 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Alveolar soft part sarcoma orbit

Nat Pernick, M.D.
Page views in 2019: 101
Page views in 2020 to date: 48
Cite this page: Pernick N. Orbit and optic nerve: alveolar soft part sarcoma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitalveolarsoftparts.html. Accessed June 1st, 2020.
Definition / general
  • Indolent, similar to tumor at other sites
  • May have late metastases
  • Mean age 23 years, range 1 - 69 years; 76% women
Microscopic (histologic) description
  • Organoid pattern outlined by thin walled capillaries, composed of nests of large polyhedral cells with abundant, finely granular, eosinophilic cytoplasm
Positive stains
  • PAS+ diastase resistant crystalline structures
Differential diagnosis
  • Alveolar rhabdomyosarcoma
  • Amelanotic melanoma
  • Granular cell tumor
  • Metastatic renal cell carcinoma
  • Paraganglioma
  • Vascular tumor
Additional references
Back to top