Eye
Orbit and optic nerve
Fibrous histiocytoma of orbit


Topic Completed: 1 February 2014

Revised: 3 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Fibrous histiocytoma [title] orbit

Nat Pernick, M.D.
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Cite this page: Pernick N. Orbit and optic nerve: fibrous histiocytoma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitfibroushistiocytoma.html. Accessed August 23rd, 2019.
Definition / general
  • Most common mesenchymal tumor of orbit in adults
  • Usually upper and nasal orbit
  • Mean age 43 years
  • Either benign, locally aggressive or malignant with recurrence rates of 31%, 57% and 64% and 10 year survival rates of 100%, 92% and 23% respectively (Hum Pathol 1982;13:199)
Radiology images

AFIP images
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MR shows a well circumscribed tumor in inferior orbit

Treatment
  • Complete surgical excision
Gross images

AFIP images
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Large, retrobulbar, well circumscribed fibrous tumor

Microscopic (histologic) description
  • Storiform pattern of fibroblast and histiocyte-like cells
  • Variable giant cells
Microscopic (histologic) images

AFIP images
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Fibrous tumor with storiform pattern

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Plump spindle cells

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Plump spindle cells with ovoid nuclei, coarse chromatin and small nucleoli

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Invasion of spindle cells into orbital adipose tissue

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