Orbit and optic nerve
Giant cell angiofibroma of orbit

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 May 2018, last major update February 2014

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Giant cell angiofibroma [title] orbit

Cite this page: Pernick, N. Orbit and optic nerve: giant cell angiofibroma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitgiantcellangio.html. Accessed December 17th, 2018.
Definition / general
  • Has features of solitary fibrous tumor and giant cell fibroblastoma of soft tissue
  • May be a giant cell rich variant of solitary fibrous tumor
  • Adults, mean age 45 years
  • In eyelid close to lacrimal gland or orbit
  • Also posterior mediastinum, upper back, submandibular, parascapular regions
  • Appears to be a slow growing tumor with occasional local recurrence
Gross description
  • Well circumscribed, nonencapsulated, mean 3 cm
Microscopic (histologic) description
  • Highly vascular with round / spindle cells, numerous thick walled vessels, collagenous or myxoid background and floret type multinucleated giant cells lining pseudovascular spaces
Positive stains