Orbit and optic nerve
Giant cell angiofibroma of orbit

Topic Completed: 1 February 2014

Minor changes: 3 April 2019

Copyright: 2004-2019, PathologyOutlines.com, Inc.

PubMed Search: Giant cell angiofibroma [title] orbit

Nat Pernick, M.D.
Page views in 2019: 157
Page views in 2020 to date: 183
Cite this page: Pernick N. Orbit and optic nerve: giant cell angiofibroma of orbit. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeorbitgiantcellangio.html. Accessed May 28th, 2020.
Definition / general
  • Has features of solitary fibrous tumor and giant cell fibroblastoma of soft tissue
  • May be a giant cell rich variant of solitary fibrous tumor
  • Adults, mean age 45 years
  • In eyelid close to lacrimal gland or orbit
  • Also posterior mediastinum, upper back, submandibular, parascapular regions
  • Appears to be a slow growing tumor with occasional local recurrence
Gross description
  • Well circumscribed, nonencapsulated, mean 3 cm
Microscopic (histologic) description
  • Highly vascular with round / spindle cells, numerous thick walled vessels, collagenous or myxoid background and floret type multinucleated giant cells lining pseudovascular spaces
Positive stains
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